Antiseptic composition.



UNITED S W ect;

ERNEST 1). REED, or DuBL-IN, mnmnmnssrenon TO THE E RY c. BLAIR company,

' or WILMINGTON, DELAWARE, A: CORPORATION or DELAWARE.

ANTISEPTIC cor/[Positron No Drawing.

To all whom it may concern:

Be it known that I, EnNEs'r'D. REED, a citizen of the United States,residing at Dublin, in the county of Wayne and State of Indiana, haveinvented certain Improvements in Antiseptic Compositions, of'which thefollowing is a specification.

My invention is an antiseptic composition designed for use as asurgicabdressing. It is produced by combining phthalicanhydrid Y with iodin andpotassium iodid and dissemi nating the product in; the form of a drypowder 'through'a mass of dry pulverized material, either inert oractive, that will serve as a mechanicaldiluent', retargl thedissociation of the unstable phthalic'anhydrid compound which resultsfrom exposure to the air or watery moisture, modify the action 0t suchcompound upon wounds and sores, and provide the bulk necessary in adressing. l The action of phthalic anhydridupon iodinand potassium.iodid produces a compound, having the. chemical formula (C H O ,KII'which cannot be used alone as a surgical dressing because it isunstable,- it readily dissociates in the air orby contact with waterymoisture, the rapid liberation of the high iodin contents of theundiluted compound causes excessive irritation, and

the amount of the undiluted compound that could be used would not havesuflicient volume for protecting exposed .surfaces or 'wounds, ulcersand the like. I Ihave found that highly useful compositions' areproduced by mechanically mixing the dry pulverized chemical (compoundedfrom phthalic anhydrid, iodinand potass'ium iodid) with variousproportions of vaorbe'nt,-drying, astringent, antiseptic. or den ulcentproperties, or properties. which stimulate the lwoundfulcer or the liketo granulation. ilAmoi g such ingredients arepurified or unpurifiedtalcum, acetanilid,

.bismuth fsubnitr ate, bismuth carbonate, hydroxid,subgallate,-a1buminate, oxychlorid,

beta-naphtholate, phenolate, tribrom'phenolnate, subsalicylate, oxyiodid'sulbgallate l' (airol), iodo bismuth anhydro'methylene '1- "buminate(bismuth formic iodid), bismuth oxyiodid', phthalate, zinc oxid,stearate, sulfocarbonate, sulfate, magnesium carbonate,-

' Specification of Letters Patent.

Patented Feb. 1d, 1911.

Application tiled May 27, 19 09.' Serial No. 498,744.

magnesium oxid, calcium carbonate, boric acid, salicylic acid, thymoIiodid, alum, terra' alba (aluminum silicate), kaolin and inert earths,The proportions of the with the anhydrid compound will vary with theingredients used, for the'purposes desired, and will be determined] bythe strength required, which may vary through comparatively wide limitsand will depend primarily onthe degreeof activity required.

Acomposition of about one part of the anhydrid compound and nine partsof. the diluent is generally very sz'ttisfacto'ry,- as in suchcomposition the iodin is released from the compound at the moderate ratethat is desired for the purposes of the dressing, the

activity of the dressing is prolonged in a de-' sired manner by thereduction in the rate of dissociationiof the compound, and the desiredbulk is obtained for protecting the sore.-

It will be understood that the composition may contain the pht-halicanhydrid compound and several substances having several propertiesspecified, the invention not being limited to a combination of twosubstances. The compositionmay contain a diluent or diluents having atthe same time drying,

antiseptic and astringent properties as in case ofa compositioncomprising ph thalic anhydrid,viodin, potassium iodid and say bismuthsalicylate, bismuth beta-naphtholate or bismuth sulfoca-rbolate, 01 allof mgmdems m e these. Or the composition may comprise a I compoundcontaining phthalic 'anhydrid, iodin, potassium iodid and a neutralsubstance having diluent properties, as talcum or magnesium carbonate,with further dilu- 'ents' having antiseptic and astringent propertie's,as bismuth salicylate, bismuth beta naphtholate'or bismuthsubsalicylate. Where the diluent is possessed of active properties itisgenerally desirable to increase the proportion thereof over theproportion that would be used where the diluent is neutral, and in the,case of the use of bismuth salicylate, bismuth, beta-naphtholateorbismuth 'sulfooarbolate, without other diluent, satis- 1. An antisepticcomposition comprising a compound of phthalic anhydrid, iodin'andpotassium iodid, and a non-liquid diluent adapted for retarding theliberation of iodin mechanically mixed therewith.

2. An antiseptic composition comprising a dry, pulverized compound ofphthalic anhydrid, iodin' and potassium iodid, and adry, pulverizeddiluent mechanically mixed therewith. 1

'3. An antiseptic composition comprising a compound of hthalic anhydrid,iodin, and potassium iodid, and a non-liquid drying substance mixedtherewith.

4. antiseptic composition comprising a compound of phthalic anhydrid,iodin and potassium iodid, and mixed therewith a non-liquid diluenthaving drying and antiseptic properties. v

5. An antiseptic composition comprising a compound of phthalic anhydrid,iodin and potassium iodid and mixed therewith a non-liquid diluenthaving drying, antiseptic I ERNEST D. REED.

W'itnesses WILLIAM E. FLOYD, ALBERT BURR.

